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Epigenetic and Metabolic Reprogramming of Fibroblasts in Crohn’s Disease Strictures Reveals Histone Deacetylases as Therapeutic Targets

5 Dec 2023

Abstract excerpt

BACKGROUND AND AIMS: No effective therapeutic intervention exists for intestinal fibrosis in Crohn's disease [CD]. We characterized fibroblast subtypes, epigenetic and metabolic changes, and signalling pathways in CD fibrosis to inform future therapeutic strategies. METHODS: We undertook immunohistochemistry, metabolic, signalling pathway and epigenetic [Transposase-Accessible Chromatin using sequencing] analyses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38069679
DOI: 10.1093/ecco-jcc/jjad209

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