Article

Butyrate modifies epigenetic and immune pathways in peripheral mononuclear cells from children with neurodevelopmental disorders associated with chromatin dysregulation

2025-07-06

Abstract excerpt

Pathogenic DNA variants in chromatin-related genes cause an important minority of neurodevelopmental disorders (NDDs). Epigenetic mechanisms, including chromatin regulation, are associated with NDD etiopathogenesis. Therapeutic strategies targeting chromatin dysregulation, such as histone deacetylase inhibition with butyrate, show promise; however, its effects remain poorly understood. We performed single-cell RNA...

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Literature Corpus work: ce0c9d76-486e-51f1-92d0-e2f5eab7ed98
DOI: 10.1101/2025.07.03.25330764

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