Article

Intercellular interaction between FAP fibroblasts and CD150 inflammatory monocytes mediates fibro-stenosis in Crohn’s disease

2023-05-04

Abstract excerpt

<h4>SUMMARY</h4> Crohn’s disease (CD) is marked by recurring intestinal inflammation and tissue injury, often resulting in fibro-stenosis and bowel obstruction, necessitating surgical intervention with high recurrence rates. To elucidate complex intercellular interactions leading to fibro-stenosis in CD, we analysed the transcriptome of cells isolated from the transmural ileum of CD patients, including a trio of...

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Literature Corpus work: ba34cb87-a318-554e-b5f9-664f13638f8c
DOI: 10.1101/2023.05.04.539383

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