Article

Stricturing Crohn’s disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions

2023-04-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Fibroblasts play a key role in stricture formation in Crohn’s disease (CD) but understanding it’s pathogenesis requires a systems-level investigation to uncover new treatment targets. We studied full thickness CD tissues to characterize fibroblast heterogeneity and function by generating the first single cell RNA sequencing (scRNAseq) atlas of strictured bowel and providing...

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Literature Corpus work: 58ed254b-f8f6-569c-8589-e6d69c71fb31
DOI: 10.1101/2023.04.03.534781

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