Article

Epithelial and stromal remodeling in murine Crohn’s disease-like ileitis

2025-11-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> Inflammatory bowel disease is characterized by progressive epithelial, immune, and stromal dysfunction. Human datasets yield important insights yet are inherently descriptive, requiring animal models for in vivo mechanistic interrogation. The SAMP1/YitFc (SAMP) mouse model develops spontaneous Crohn’s disease (CD)-like ileitis while allowing controlled manipulation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 852065ce-2f84-5c8e-a170-869c59f25e8a
DOI: 10.1101/2025.11.08.684908

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epithelial and stromal remodeling in murine Crohn’s disease-like ileitisDOI 10.1101/2025.11.08.684908Read

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn’s Disease PathogenesisSemantic proximity Read

Organization of the human intestine at single-cell resolutionSemantic proximity Read

High Resolution Single Cell Maps Reveals Distinct Cell Organization and Function Across Different Regions of the Human IntestineSemantic proximity Read

Integration of single-cell transcriptome and genetic profiles reveals critical cell types and genes in inflammatory bowel diseaseSemantic proximity Read

Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockadeSemantic proximity Read

Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naïve Adult Crohn’s Disease PatientsSemantic proximity Read

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolutionSemantic proximity Read

Decoding the mosaic of inflammatory bowel disease: Illuminating insights with single-cell RNA technologySemantic proximity Read

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodelingSemantic proximity Read

Immune signaling mediates stromal changes to support epithelial reprogramming in celiac duodenumSemantic proximity Read

Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac diseaseSemantic proximity Read

A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn’s DiseaseSemantic proximity Read