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Novel Transcriptomic Signatures in Fibrostenotic Crohn’s Disease: Dysregulated Pathways, Promising Biomarkers, and Putative Therapeutic Targets

23 Jan 2025

Abstract excerpt

BACKGROUND: Fibrosis is a common complication in Crohn's disease (CD), often leading to intestinal strictures. This study aims to explore the transcriptomic signature of fibrostenotic ileal CD for a comprehensive characterization of biological and cellular mechanisms underlying intestinal fibrosis. METHODS: Nine CD patients undergoing surgery for fibrotic ileal strictures were prospectively recruited. RNA was...

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PMID: 39977234
DOI: 10.1093/ibd/izaf021

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