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Article

Fatty Acid Oxidation Suppression Reprograms Fibroblasts in Fibrostenotic Crohn’s Disease

2026-05-10

Abstract excerpt

Fibrostenotic complications represent a major cause of morbidity in Crohn’s disease (CD), yet the cellular mechanisms that drive intestinal fibrosis independent of active inflammation remain poorly understood. Here, we identify impaired fatty acid oxidation (FAO) as a defining metabolic feature of fibroblasts in fibrostenotic CD. Untargeted lipidomics of non-inflamed colonic tissue from CD patients demonstrated en...

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Literature Corpus work
3bb5668f-b942-574b-b8f7-aa8c642a0cbc
DOI
10.64898/2026.05.06.723289
Open publication

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Fatty Acid Oxidation Suppression Reprograms Fibroblasts in Fibrostenotic Crohn’s DiseaseDOI 10.64898/2026.05.06.723289
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