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Epigenetics in Liver Fibrosis: Could HDACs be a Therapeutic Target?

19 Oct 2020

Abstract excerpt

Chronic liver diseases (CLD) represent a worldwide health problem. While CLDs may have diverse etiologies, a common pathogenic denominator is the presence of liver fibrosis. Cirrhosis, the end-stage of CLD, is characterized by extensive fibrosis and is markedly associated with the development of hepatocellular carcinoma. The most important event in hepatic fibrogenesis is the activation of hepatic stellate cells...

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PMID: 33086678
DOI: 10.3390/cells9102321

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