Genetic risk converges on regulatory networks mediating early type 2 diabetes.

doi:10.1038/s41586-023-06693-2

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Article

Genetic risk converges on regulatory networks mediating early type 2 diabetes.

Nature - 1 Dec 2023

Walker John T, Saunders Diane C, Rai Vivek, Chen Hung-Hsin, Orchard Peter, Dai Chunhua, Pettway Yasminye D, Hopkirk Alexander L, Reihsmann Conrad V, Tao Yicheng, Fan Simin, Shrestha Shristi, Varshney Arushi, Petty Lauren E, Wright Jordan J, Ventresca Christa, Agarwala Samir, Aramandla Radhika, Poffenberger Greg, Jenkins Regina, Mei Shaojun, Hart Nathaniel J, Phillips Sharon, Kang Hakmook, Greiner Dale L, Shultz Leonard D, Bottino Rita, Liu Jie, Below Jennifer E, Parker Stephen C J, Powers Alvin C, Brissova Marcela

Abstract excerpt

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is characterized by dysfunction of insulin-producing pancreatic islet β cells1,2. T2D genome-wide association studies (GWAS) have identified hundreds of signals in non-coding and β cell regulatory genomic regions, but deciphering their biological mechanisms remains challenging3-5. Here, to identify early disease-driving events, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38049589
DOI: 10.1038/s41586-023-06693-2
PMCID: PMC11374460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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