Article

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

2020-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as pancreatic islets. Here, we investigated contributions of regulatory programs active during pancreatic development to T2D risk. Generation of chromatin maps from developmental precursors throughout pancreatic differentiation of human embryonic stem cells (hESCs) identifie...

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Literature Corpus work: c516f819-10f0-5b83-a008-53f3f007a413
DOI: 10.1101/2020.05.18.101071

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