Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

5 Feb 2021

Abstract excerpt

Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as pancreatic islets. Here, we investigated contributions of regulatory programs active during pancreatic development to T2D risk. Generation of chromatin maps from developmental precursors throughout pancreatic differentiation of human embryonic stem cells (hESCs) identifies enrichment of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetics and Neurodevelopmental Disorders
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33544077
DOI: 10.7554/elife.59067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in developmentPMID 33544077Read ↗

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in developmentSemantic proximity Read ↗

eQTL mapping in fetal-like pancreatic progenitor cells reveals early developmental insights into diabetes riskSemantic proximity Read ↗

The three-dimensional chromatin structure of the major human pancreatic cell types reveals lineage-specific regulatory architecture of T2D riskSemantic proximity Read ↗

Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition.Semantic proximity Read ↗

eQTL mapping in fetal-like pancreatic progenitor cells reveals early developmental insights into diabetes risk.Semantic proximity Read ↗

A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas.Semantic proximity Read ↗

Single-Cell Multi-Omic Roadmap of Human Fetal Pancreatic DevelopmentSemantic proximity Read ↗

Latent plasticity of the human pancreas across development, health, and diseaseSemantic proximity Read ↗

Regulatory variants active in iPSC-derived pancreatic progenitor cells are associated with Type 2 Diabetes in adultsSemantic proximity Read ↗

From Genetic Association to Molecular Mechanisms for Islet-cell Dysfunction in Type 2 Diabetes.Semantic proximity Read ↗

Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetesSemantic proximity Read ↗

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin SecretionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.