Article

Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues

2025-05-07

Abstract excerpt

Type 2 diabetes (T2D) is a prevalent disease that arises from complex molecular mechanisms. Here, we leverage T2D multi-ancestry genetic associations to identify causal molecular mechanisms in an ancestry- and tissue-aware manner. Using two-sample Mendelian Randomization corroborated by colocalization across four global ancestries, we analyze 20,307 gene and 1,630 protein expression levels using blood-derived cis...

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Literature Corpus work: 2a9fe14d-12af-547b-a554-d460c962ef91
DOI: 10.1101/2025.05.05.25326880

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