Article
Colocalization of eQTLs With Type 2 Diabetes and Glycemic Traits Using Whole-Genome Sequences in Diverse Populations From the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program.
Diabetes - 1 Aug 2026
Wang Ningyuan, DiCorpo Daniel A, Zhang Yixin, Kleinbrink Erica, Arnett Donna K, Barnard John, Blangero John, Bowden Donald W, Carson April P, Chen Yii-Der Ida, Chung Mina K, Curran Joanne E, Darbar Dawood, Duggirala Ravindranath, Ellinor Patrick T, Fatkin Diane, Fornage Myriam, Heard-Costa Nancy, He Jiang, Hou Lifang, Kardia Sharon L R, Kooperberg Charles, Loos Ruth J F, McManus David D, Mitchell Braxton D, Minster Ryan L, North Kari E, Psaty Bruce M, Raffield Laura M, Redline Susan, Rich Stephen S, Roden Dan, Rotter Jerome I, Shoemaker Moore B, Smith Jonathan D, Van Wagoner David R, Aguet Francois, Ardlie Kristin, Bis Joshua C, Brody Jennifer A, Cade Brian E, Clish Clary B, de Vries Paul S, Floyd James S, Freedman Barry I, Gabriel Stacey, Gerzsten Robert E, Goodarzi Mark O, Gu Charles, Guo Xiuqing, Gupta Namrata, Heckbert Susan R, Hsu Sarah, Hung Yi-Jen, Kalyani Rita R, Kelly Tanika N, Kinney Gregory L, Li Changwei, Liu Simin, Liu Yongmei, Lloyd-Jones Donald M, Manson JoAnn E, Mathias Rasika A, Mercader Josep M, Morrison Alanna C, Naseri Take, Onengut Suna, Palmer Nicholette D, Peyser Patricia A, Qi Qibin, Raghavan Sridharan, Reiner Alex P, Rooney Mary R, Sevilla-Gonzalez Magdalena, Sarnowski Chloe, Smith Joshua D, Smith Jennifer A, Spartano Nicole L, Tahir Usman, Taylor Kent D, Tobias Deirdre K, Tracy Russel P, Viali Satupa'itea, Wang Heming, Wood Alexis C, Yanek Lisa R, Zhao Wei, Zheng Yinan, Dupuis Josée, Liu Ching-Ti, Sladek Robert, Wessel Jennifer, Meigs James B, Manning Alisa K
Abstract excerpt
Large-scale multiancestry genome-wide association studies have identified hundreds of loci associated with type 2 diabetes (T2D) and glycemic traits, yet imputed genotyping arrays limit the detection of low-frequency and rare variants. Whole-genome sequencing (WGS) offers a more complete view of genetic variation, especially across diverse populations. We analyzed high-coverage (38×) WGS data from 21,913 T2D case...
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