Article

RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes

2021-12-17

Abstract excerpt

<h4>SUMMARY</h4> A hallmark of type 2 diabetes (T2D), a major cause of world-wide morbidity and mortality, is dysfunction of insulin-producing pancreatic islet β cells 1–3 . T2D genome-wide association studies (GWAS) have identified hundreds of signals, mostly in the non-coding genome and overlapping β cell regulatory elements, but translating these into biological mechanisms has been challenging 4–6 . To ident...

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Literature Corpus work: 3a5f4ce1-fc35-595a-9ee9-fadd4f18f5ac
DOI: 10.1101/2021.12.16.466282

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