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Article

The PIM kinases in hematological cancers

25 Jan 2012

Abstract excerpt

The PIM genes represent a family of proto-oncogenes that encode three different serine/threonine protein kinases (PIM1, PIM2 and PIM3) with essential roles in the regulation of signal transduction cascades, which promote cell survival, proliferation and drug resistance. PIM kinases are overexpressed in several hematopoietic tumors and support in vitro and in vivo malignant cell growth and survival, through cell...

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Identifiers

PMID: 22272708
DOI: 10.1586/ehm.11.69

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