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Targeting PIM Kinases to Overcome Therapeutic Resistance in Cancer

1 Jan 2021

Abstract excerpt

Cancer progression and the onset of therapeutic resistance are often the results of uncontrolled activation of survival kinases. The proviral integration for the Moloney murine leukemia virus (PIM) kinases are oncogenic serine/threonine kinases that regulate tumorigenesis by phosphorylating a wide range of substrates that control cellular metabolism, proliferation, and survival. Because of their broad impact on...

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PMID: 33303645
DOI: 10.1158/1535-7163.mct-20-0535

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