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Protein kinase PIM2: A simple PIM family kinase with complex functions in cancer metabolism and therapeutics

1 Jan 2021

Abstract excerpt

PIM2 (proviral integration site for Moloney murine leukemia virus 2) kinase plays an important role as an oncogene in multiple cancers, such as leukemia, liver, lung, myeloma, prostate and breast cancers. PIM2 is largely expressed in both leukemia and solid tumors, and it promotes the transcriptional activation of genes involved in cell survival, cell proliferation, and cell-cycle progression. Many tumorigenic...

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PMID: 33854618
DOI: 10.7150/jca.53134

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