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Article

Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2002

Rainio Eeva-Marja, Sandholm Jouko, Koskinen Päivi J

Abstract excerpt

Pim-1 is an oncogenic serine/threonine kinase implicated in cytokine-induced signal transduction and in development of lymphoid malignancies. However, its precise function as well as physiological substrates have remained unknown. In this study we demonstrate that Pim-1 can physically interact with the NFATc1 transcription factor and phosphorylate it in vitro on several serine residues. In contrast to previously...

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Identifiers

PMID: 11823475
DOI: 10.4049/jimmunol.168.4.1524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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