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Article

Proviral integration site 2 is required for interleukin-6 expression induced by interleukin-1, tumour necrosis factor-α and lipopolysaccharide.

Immunology - 1 Oct 2010

Yang Jianfei, Li Xiang, Hanidu Adedayo, Htut Tin M, Sellati Rosemarie, Wang Lian, Jiang Huiping, Li Jun

Abstract excerpt

PIM (proviral integration site) kinases are a distinct class of serine/threonine-specific kinases consisting of PIM1, PIM2 and PIM3. PIM2 is known to function in apoptosis pathways. Expression of PIM2 is highly induced by pro-inflammatory stimuli but the role of PIM2 in the expression of pro-inflammatory cytokines is unclear. In this study, we showed that over-expression of PIM2 in HeLa cells as well as in human...

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Identifiers

PMID: 20465571
DOI: 10.1111/j.1365-2567.2010.03286.x
PMCID: PMC2967263

Genes

PIM2
PIM1
PIM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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