Article

scHLAcount: Allele-specific HLA expression from single-cell gene expression data

2019-08-29

Abstract excerpt

Studies in bulk RNA sequencing data suggest cell-type and allele-specific expression of the human leukocyte antigen (HLA) genes. These loci are extremely diverse and they function as part of the major histocompatibility complex (MHC) which is responsible for antigen presentation. Mutation and or misregulation of expression of HLA genes has implications in diseases, especially cancer. Immune responses to tumor cell...

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Literature Corpus work: cf8145f2-6b6a-59f5-8342-5ef34a1eeb41
DOI: 10.1101/750612

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