Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci.

Nature genetics - 1 Mar 2020

Gutierrez-Arcelus Maria, Baglaenko Yuriy, Arora Jatin, Hannes Susan, Luo Yang, Amariuta Tiffany, Teslovich Nikola, Rao Deepak A, Ermann Joerg, Jonsson A Helena, Navarrete Cristina, Rich Stephen S, Taylor Kent D, Rotter Jerome I, Gregersen Peter K, Esko Tonu, Brenner Michael B, Raychaudhuri Soumya

Abstract excerpt

Genetic studies have revealed that autoimmune susceptibility variants are over-represented in memory CD4+ T cell regulatory elements1-3. Understanding how genetic variation affects gene expression in different T cell physiological states is essential for deciphering genetic mechanisms of autoimmunity4,5. Here, we characterized the dynamics of genetic regulatory effects at eight time points during memory CD4+ T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmunity
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR-Cas Systems

Share to HLA Antigens

Share to HLA-DQ beta-Chains

Share to Immunity, Cellular

Share to Lymphocyte Activation

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 32066938
DOI: 10.1038/s41588-020-0579-4
PMCID: PMC7135372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci.PMID 32066938Read ↗

Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease.Semantic proximity Read ↗

Mapping the dynamic genetic regulatory architecture of<i>HLA</i>genes at single-cell resolutionSemantic proximity Read ↗

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation.Semantic proximity Read ↗

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.Semantic proximity Read ↗

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elementsSemantic proximity Read ↗

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activationSemantic proximity Read ↗

Linking candidate causal autoimmune variants to T cell networks using genetic and epigenetic screens in primary human T cellsSemantic proximity Read ↗

Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases.Semantic proximity Read ↗

Integration of genetic and epigenetic data pinpoints autoimmune specific remodelling of enhancer landscape in CD4+ T cellsSemantic proximity Read ↗

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunitySemantic proximity Read ↗

Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets.Semantic proximity Read ↗

Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.