Global patterns of cis variation in human cells revealed by high-density allelic expression analysis.

doi:10.1038/ng.473

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Article

Global patterns of cis variation in human cells revealed by high-density allelic expression analysis.

Nature genetics - 1 Nov 2009

Ge Bing, Pokholok Dmitry K, Kwan Tony, Grundberg Elin, Morcos Lisanne, Verlaan Dominique J, Le Jennie, Koka Vonda, Lam Kevin C L, Gagné Vincent, Dias Joana, Hoberman Rose, Montpetit Alexandre, Joly Marie-Michele, Harvey Edward J, Sinnett Daniel, Beaulieu Patrick, Hamon Robert, Graziani Alexandru, Dewar Ken, Harmsen Eef, Majewski Jacek, Göring Harald H H, Naumova Anna K, Blanchette Mathieu, Gunderson Kevin L, Pastinen Tomi

Abstract excerpt

Cis-acting variants altering gene expression are a source of phenotypic differences. The cis-acting components of expression variation can be identified through the mapping of differences in allelic expression (AE), which is the measure of relative expression between two allelic transcripts. We generated a map of AE associated SNPs using quantitative measurements of AE on Illumina Human1M BeadChips. In 53...

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PMID: 19838192
DOI: 10.1038/ng.473

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