Article
Risk-reducing mastectomy and breast cancer mortality in women with a BRCA1 or BRCA2 pathogenic variant: an international analysis.
British journal of cancer - 1 Feb 2024
Metcalfe Kelly, Huzarski Tomasz, Gronwald Jacek, Kotsopoulos Joanne, Kim Raymond, Moller Pal, Pal Tuya, Aeilts Amber, Eisen Andrea, Karlan Beth, Bordeleau Louise, Tung Nadine, Olopade Olufunmilayo, Zakalik Dana, Singer Christian F, Foulkes William, Couch Fergus, Neuhausen Susan L, Eng Charis, Sun Ping, Lubinski Jan, Narod Steven A
Abstract excerpt
BACKGROUND: Risk-reducing mastectomy (RRM) is offered to women with a BRCA1 or BRCA2 pathogenic variant, however, there are limited data on the impact on breast cancer mortality. METHODS: Participants were identified from a registry of women with BRCA1/2 pathogenic variants. We used a pseudo-randomised trial design and matched one woman with a RRM to one woman without a RRM on year of birth, gene, and country. We...
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