Association between risk-reducing surgeries and survival in young BRCA carriers with breast cancer: an international cohort study.

doi:10.1016/S1470-2045(25)00152-4

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Article

Association between risk-reducing surgeries and survival in young BRCA carriers with breast cancer: an international cohort study.

The Lancet. Oncology - 1 Jun 2025

Blondeaux Eva, Sonnenblick Amir, Agostinetto Elisa, Bas Raphaëlle, Kim Hee J, Franzoi Maria A, Bernstein-Molho Rinat, Linn Sabine, Kwong Ava, Pogoda Katarzyna, Balmana Judith, Smeets Ann, Bajpai Jyoti, Moore Halle C F, Partridge Ann H, Phillips Kelly-Anne, Toss Angela, Rousset-Jablonski Christine, Peccatori Fedro A, Renaud Tiphaine, Ferrari Alberta, Paluch-Shimon Shani, Mando Pablo, Lee Jeong E, Fruscio Robert, Cui Wanda, Wong Stephanie M, Vernieri Claudio, Ruddy Kathryn J, Dieci Maria V, Matikas Alexios, Rozenblit Mariya, Guven Deniz C, Lee Minna, Villarreal-Garza Cynthia, Hwang Shelley E, De Marchis Laura, Puglisi Fabio, Kemp Zoe, Meireles Pedro A, Parokonnaya Anastasia, Werutsky Gustavo, Okano Maiko, Azim Hatem A, Mati Kleida, Rosenberg Shoshana, Gelber Richard, Boni Luca, Lambertini Matteo

Abstract excerpt

BACKGROUND: Little evidence exists on the effect of risk-reducing surgeries in young BRCA carriers with a previous history of breast cancer. We investigated the association between risk-reducing mastectomy (RRM) or risk-reducing salpingo-oophorectomy (RRSO), or both procedures, with survival outcomes in a large global cohort of young BRCA carriers with previous breast cancer. METHODS: The BRCA BCY Collaboration...

Topics

Humans
Female
Breast Neoplasms
Adult
Retrospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

BRCA1 Protein

BRCA2 Protein

Prophylactic Mastectomy

Salpingo-oophorectomy

Germ-Line Mutation

Heterozygote

Genetic Predisposition to Disease

Source

Open in PubMed

Identifiers

PMID: 40347973
DOI: 10.1016/S1470-2045(25)00152-4

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Association between risk-reducing surgeries and survival in young BRCA carriers with breast cancer: an international cohort study.PMID 40347973Read ↗

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