Article
The risks of cancer in older women with BRCA pathogenic variants: How far have we come?
Cancer - 15 Mar 2023
Metcalfe Kelly A, Gronwald Jacek, Tung Nadine M, McCuaig Jeanna M, Eisen Andrea, Elser Christine, Foulkes William D, Neuhausen Susan L, Senter Leigha, Moller Pal, Bordeleau Louise, Fruscio Robert, Velsher Lea, Zakalik Dana, Olopade Olufunmilayo I, Eng Charis, Pal Tuya, Cullinane Carey A, Couch Fergus J, Kotsopoulos Joanne, Sun Ping, Lubinski Jan, Narod Steven A
Abstract excerpt
BACKGROUND: The purpose of this study was to estimate the cumulative risks of all cancers in women from 50 to 75 years of age with a BRCA1 or BRCA2 pathogenic variant. METHODS: Participants were women with BRCA1 or BRCA2 pathogenic variants from 85 centers in 16 countries. Women were eligible if they had no cancer before the age of 50 years. Participants completed a baseline questionnaire and follow-up...
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