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Article

Survival Outcomes With or Without Risk-Reducing Mastectomy in BRCA1 and BRCA2 Pathogenic Variant Carriers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2026

Gandhi Ashu, Howell Sacha J, Harkness Elaine F, Woodward Emma, Lalloo Fiona, Forde Claire, Harvey James, Highton Lyndsey, Flaum Nicola, Evans D Gareth

Abstract excerpt

PURPOSE: Many women carrying pathogenic variants (pvs) of BRCA1 and BRCA2 genes (pvBRCA1/2) elect to undergo bilateral risk-reducing mastectomy (BRRM) in the belief that it will improve their overall survival (OS). Although many are satisfied with their decision to undergo BRRM a significant minority exhibit regret. We compared long-term oncology outcomes in women with pvBRCA1/2 choosing BRRM with those choosing...

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Identifiers

PMID: 41637687
DOI: 10.1200/JCO-25-00834

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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