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Article

Risk management decisions in women with BRCA1 and BRCA2 mutations.

American journal of surgery - 1 May 2018

Morgan Rosemary, Brown Audrey, Hamman Kelly Jo, Sampson Jone, Naik Arpana, Massimino Kristen

Abstract excerpt

INTRODUCTION: Pathogenic mutations and variants of uncertain significance (VUS) occur in BRCA1/2 genes. METHODS: Records of women with a pathogenic mutation or VUS in BRCA1/2 treated between 2008 and 2017 were reviewed. RESULTS: One hundred and ten women were included. Mean age was 47. A pathogenic mutation or a VUS in BRCA1/2 was detected in 85 (77%) and 25 (23%) patients, respectively. The rate of risk reducing...

Topics

Adolescent
Adult
Aged
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Decision Making
Female
Genetic Testing
Humans
Mastectomy
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Risk Management

Risk Reduction Behavior

Watchful Waiting

Source

Identifiers

PMID: 29499861
DOI: 10.1016/j.amjsurg.2018.02.010

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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