Article
Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality.
JAMA - 1 Sept 2010
Domchek Susan M, Friebel Tara M, Singer Christian F, Evans D Gareth, Lynch Henry T, Isaacs Claudine, Garber Judy E, Neuhausen Susan L, Matloff Ellen, Eeles Rosalind, Pichert Gabriella, Van t'veer Laura, Tung Nadine, Weitzel Jeffrey N, Couch Fergus J, Rubinstein Wendy S, Ganz Patricia A, Daly Mary B, Olopade Olufunmilayo I, Tomlinson Gail, Schildkraut Joellen, Blum Joanne L, Rebbeck Timothy R
Abstract excerpt
CONTEXT: Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 or BRCA2 mutations to reduce their risks of breast and ovarian cancer. OBJECTIVE: To estimate risk and mortality reduction stratified by mutation and prior cancer status. DESIGN, SETTING, AND PARTICIPANTS: Prospective, multicenter cohort study of 2482 women with BRCA1 or BRCA2 mutations ascertained between 1974 and 2008. The study...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.