Oncological safety and preventive impact of nipple-sparing mastectomy in patients with BRCA1/2 mutation: multicentre study of the Korea Robot-endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG).

doi:10.1093/bjsopen/zraf168

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Oncological safety and preventive impact of nipple-sparing mastectomy in patients with BRCA1/2 mutation: multicentre study of the Korea Robot-endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG).

BJS open - 29 Dec 2025

Kim Hong-Kyu, Shin Dong Seung, Jang Sung Yoon, Bae Soong June, Kim Eun Young, Cha Chihwan David, Park Hyung Seok, Lee Jeeyeon, Lee Jun-Hee, Lee Eun-Shin, Choi Jung Eun, Bae Soo Youn, Shin Hee-Chul, Kim Dongwon, Lee Moo Hyun, Kim Yong-Yeup, Han Sang-Ah, Lee Janghee, Chang Young Woo, Min Junwon, Kim Sanghwa, Kang Young-Joon, Choi Hee Jun, Lee Sae Byul, Ryu Jai Min

Abstract excerpt

BACKGROUND: Nipple-sparing mastectomy (NSM) is a surgical option offering both oncological safety and cosmetic benefits. However, the oncological safety of NSM in carriers of BRCA1/2 pathogenic variants/likely pathogenic variants (PV/LPV) with breast cancer and the role of risk-reducing mastectomy remain underexplored, especially in Asian populations. This study evaluated the safety and effectiveness of NSM in...

Topics

Humans
Female
Middle Aged
Republic of Korea
Breast Neoplasms
Retrospective Studies
Adult
Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nipples

Aged, 80 and over

Neoplasm Recurrence, Local

BRCA1 Protein

Young Adult

BRCA2 Protein

Genes, BRCA2

Genes, BRCA1

Mutation

Prophylactic Mastectomy

Source

Open in PubMed Open full text

Identifiers

PMID: 41701219
DOI: 10.1093/bjsopen/zraf168
PMCID: PMC12911035

Genes

BRCA1
BSG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Oncological safety and preventive impact of nipple-sparing mastectomy in patients with BRCA1/2 mutation: multicentre study of the Korea Robot-endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG).PMID 41701219Read ↗

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