Risk-reducing mastectomy and salpingo-oophorectomy in women with hereditary breast and ovarian cancer: a single-institute experience following coverage by Japanese national medical insurance.

doi:10.1093/jjco/hyaf193

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Risk-reducing mastectomy and salpingo-oophorectomy in women with hereditary breast and ovarian cancer: a single-institute experience following coverage by Japanese national medical insurance.

Japanese journal of clinical oncology - 13 Mar 2026

Yamada Akimitsu, Oshi Masanori, Isa Takumi, Koyasu Tomohiro, Takatsuka Mii, Kuriki Hiroko, Isoda Maya, Kawashima Kei, Sasamoto Mahato, Matsubara Yuka, Adachi Shoko, Ogawara Yuki, Imai Yuichi, Ishidera Yumi, Mizushima Taichi, Hamanoue Haruka, Narui Kazutaka, Yoshida Tatsuya, Suganuma Nobuyasu, Saito Aya, Miyagi Etsuko, Ishikawa Takashi, Endo Itaru

Abstract excerpt

BACKGROUND: Risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) are preventive options for women with hereditary breast and ovarian cancer (HBOC). The Japanese national medical insurance began covering RRM and RRSO for patients with HBOC in April 2020. METHODS: We retrospectively analyzed 59 individuals with pathogenic germline variants (PGVs) from 55 families diagnosed with HBOC between...

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PMID: 41342555
DOI: 10.1093/jjco/hyaf193

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BRCA2

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Risk-reducing mastectomy and salpingo-oophorectomy in women with hereditary breast and ovarian cancer: a single-institute experience following coverage by Japanese national medical insurance.PMID 41342555Read ↗

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