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SIRT1 Prevents R-Loops during Chronological Aging by Modulating DNA Replication at rDNA Loci

15 Nov 2023

Abstract excerpt

In metazoans, the largest sirtuin, SIRT1, is a nuclear protein implicated in epigenetic modifications, circadian signaling, DNA recombination, replication, and repair. Our previous studies have demonstrated that SIRT1 binds replication origins and inhibits replication initiation from a group of potential initiation sites (dormant origins). We studied the effects of aging and SIRT1 activity on replication origin...

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PMID: 37998365
DOI: 10.3390/cells12222630

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