Article
Revisiting the bad luck hypothesis: Cancer risk and aging are linked to replication-driven changes to the epigenome
2022-09-17
Abstract excerpt
Aging is the leading risk factor for cancer. While it’s been proposed that the age-related accumulation of somatic mutations drives this relationship, it is likely not the full story. Here, we show that both aging and cancer share a common epigenetic replication signature, which we modeled from DNA methylation data in extensively passaged immortalized human cells in vitro and tested on clinical tissues. This epig...
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Identifiers and source
- Literature Corpus work
- 6cb82a46-de51-5590-8830-c28322be8b66
- DOI
- 10.1101/2022.09.14.507975