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Article

Progressive loss of SIRT1 with cell cycle withdrawal

25 Aug 2006

Abstract excerpt

Sir2 is an NAD+-dependent deacetylase that regulates lifespan in yeast, worms and flies. The mammalian orthologs of Sir2 include SIRT1 in humans and mice. In this study, we analyzed the level of SIRT1 in human lung fibroblasts (IMR90) and mouse embryonic fibroblasts (MEFs) from mice with normal, accelerated, and delayed aging. SIRT1 protein, but not mRNA, decreased significantly with serial cell passage in both...

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PMID: 16939484
DOI: 10.1111/j.1474-9726.2006.00235.x

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