Article
An interplay between multiple sirtuins promotes completion of DNA replication in cells with short telomeres.
PLoS genetics - 1 Apr 2018
Simoneau Antoine, Ricard Étienne, Wurtele Hugo
Abstract excerpt
The evolutionarily-conserved sirtuin family of histone deacetylases regulates a multitude of DNA-associated processes. A recent genome-wide screen conducted in the yeast Saccharomyces cerevisiae identified Yku70/80, which regulate nonhomologous end-joining (NHEJ) and telomere structure, as being essential for cell proliferation in the presence of the pan-sirtuin inhibitor nicotinamide (NAM). Here, we show that...
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