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Article

R Loops and Their Composite Cancer Connections.

Trends in cancer - 1 Oct 2019

Wells James P, White Justin, Stirling Peter C

Abstract excerpt

R loops are three-stranded nucleic acid structures consisting of an RNA molecule that has invaded duplex DNA. R-loop structures have normal functions in regulating gene expression, class-switch recombination, telomere stability, and mitochondrial DNA replication. However, unscheduled R-loop accumulation is a driver of DNA replication stress and genome instability. Meanwhile, R loops and associated...

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Identifiers

PMID: 31706509
DOI: 10.1016/j.trecan.2019.08.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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