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Article

SIRT7: a sentinel of genome stability

1 Jun 2021

Abstract excerpt

SIRT7 is a class III histone deacetylase that belongs to the sirtuin family. The past two decades have seen numerous breakthroughs in terms of understanding SIRT7 biological function. We now know that this enzyme is involved in diverse cellular processes, ranging from gene regulation to genome stability, ageing and tumorigenesis. Genomic instability is one hallmark of cancer and ageing; it occurs as a result of...

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PMID: 34129782
DOI: 10.1098/rsob.210047

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