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Article

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

6 Jun 2020

Abstract excerpt

SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism and stress responses. It remains elusive how human somatic stem cell populations might be impacted by SIRT7. Here, we found that SIRT7 expression declines during human mesenchymal stem cell (hMSC) aging and that SIRT7 deficiency accelerates senescence. Mechanistically, SIRT7 forms a complex with nuclear lamina proteins...

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PMID: 32504224
DOI: 10.1007/s13238-020-00728-4

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