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Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability

11 May 2017

Abstract excerpt

Chromatin structure affects DNA replication patterns, but the role of specific chromatin modifiers in regulating the replication process is yet unclear. We report that phosphorylation of the human SIRT1 deacetylase on Threonine 530 (T530-pSIRT1) modulates DNA synthesis. T530-pSIRT1 associates with replication origins and inhibits replication from a group of 'dormant' potential replication origins, which initiate...

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PMID: 28549174
DOI: 10.1093/nar/gkx468

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