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Article

The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability

4 May 2018

Abstract excerpt

, genomic instability in rDNA repeat sequences is an underlying cause of cell aging and is suppressed by the chromatin-silencing factor Sir2. In humans, rDNA instability is observed in cancers and premature aging syndromes, but its underlying mechanisms and functional consequences remain unclear. Here, we uncovered a pivotal role of sirtuin 7 (SIRT7), a mammalian Sir2 homolog, in guarding against rDNA instability...

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PMID: 29728458
DOI: 10.1074/jbc.ac118.003325

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