Article
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.
PLoS genetics - 1 Apr 2011
Van Tyne Daria, Park Daniel J, Schaffner Stephen F, Neafsey Daniel E, Angelino Elaine, Cortese Joseph F, Barnes Kayla G, Rosen David M, Lukens Amanda K, Daniels Rachel F, Milner Danny A, Johnson Charles A, Shlyakhter Ilya, Grossman Sharon R, Becker Justin S, Yamins Daniel, Karlsson Elinor K, Ndiaye Daouda, Sarr Ousmane, Mboup Souleymane, Happi Christian, Furlotte Nicholas A, Eskin Eleazar, Kang Hyun Min, Hartl Daniel L, Birren Bruce W, Wiegand Roger C, Lander Eric S, Wirth Dyann F, Volkman Sarah K, Sabeti Pardis C
Abstract excerpt
The Plasmodium falciparum parasite's ability to adapt to environmental pressures, such as the human immune system and antimalarial drugs, makes malaria an enduring burden to public health. Understanding the genetic basis of these adaptations is critical to intervening successfully against malaria. To that end, we created a high-density genotyping array that assays over 17,000 single nucleotide polymorphisms (∼ 1...
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