Article
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
Nature genetics - 1 Mar 2015
Miotto Olivo, Amato Roberto, Ashley Elizabeth A, MacInnis Bronwyn, Almagro-Garcia Jacob, Amaratunga Chanaki, Lim Pharath, Mead Daniel, Oyola Samuel O, Dhorda Mehul, Imwong Mallika, Woodrow Charles, Manske Magnus, Stalker Jim, Drury Eleanor, Campino Susana, Amenga-Etego Lucas, Thanh Thuy-Nhien Nguyen, Tran Hien Tinh, Ringwald Pascal, Bethell Delia, Nosten Francois, Phyo Aung Pyae, Pukrittayakamee Sasithon, Chotivanich Kesinee, Chuor Char Meng, Nguon Chea, Suon Seila, Sreng Sokunthea, Newton Paul N, Mayxay Mayfong, Khanthavong Maniphone, Hongvanthong Bouasy, Htut Ye, Han Kay Thwe, Kyaw Myat Phone, Faiz Md Abul, Fanello Caterina I, Onyamboko Marie, Mokuolu Olugbenga A, Jacob Christopher G, Takala-Harrison Shannon, Plowe Christopher V, Day Nicholas P, Dondorp Arjen M, Spencer Chris C A, McVean Gilean, Fairhurst Rick M, White Nicholas J, Kwiatkowski Dominic P
Abstract excerpt
We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domains, which were associated with a slow parasite clearance rate after treatment with artemisinin derivatives....
Topics
Join the communities discussing this publication.