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Article

Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance.

Nature communications - 30 Dec 2024

Ngwana-Joseph Gabrielle C, Phelan Jody E, Manko Emilia, Dombrowski Jamille G, da Silva Santos Simone, Suarez-Mutis Martha, Vélez-Tobón Gabriel, Tobón Castaño Alberto, Machado Ricardo Luiz Dantas, Marinho Claudio R F, Nolder Debbie, Nosten François, Sutherland Colin J, Campino Susana, Clark Taane G

Abstract excerpt

Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions have led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine instead. However, the molecular drivers of CQR remain unclear. Using a genome-wide approach, we perform a genomic analysis of 1534 P. vivax isolates across 29 endemic countries, detailing population structure, patterns of relatedness,...

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Identifiers

PMID: 39738010
DOI: 10.1038/s41467-024-54964-x
PMCID: PMC11685768

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