Article
Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance.
Nature communications - 30 Dec 2024
Ngwana-Joseph Gabrielle C, Phelan Jody E, Manko Emilia, Dombrowski Jamille G, da Silva Santos Simone, Suarez-Mutis Martha, Vélez-Tobón Gabriel, Tobón Castaño Alberto, Machado Ricardo Luiz Dantas, Marinho Claudio R F, Nolder Debbie, Nosten François, Sutherland Colin J, Campino Susana, Clark Taane G
Abstract excerpt
Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions have led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine instead. However, the molecular drivers of CQR remain unclear. Using a genome-wide approach, we perform a genomic analysis of 1534 P. vivax isolates across 29 endemic countries, detailing population structure, patterns of relatedness,...
Topics
- Plasmodium vivax
- Drug Resistance
- Antimalarials
- Humans
- Malaria, Vivax
- Polymorphism, Single Nucleotide
- Indonesia
- Chloroquine
- Quinolines