Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide direct quantification of in vivo mutagenesis using high-accuracy paired-end and complementary consensus sequencing.

Nucleic acids research - 27 Nov 2023

You Xinyue, Cao Yiyi, Suzuki Takayoshi, Shao Jie, Zhu Benzhan, Masumura Kenichi, Xi Jing, Liu Weiying, Zhang Xinyu, Luan Yang

Abstract excerpt

Error-corrected next-generation sequencing (ecNGS) is an emerging technology for accurately measuring somatic mutations. Here, we report paired-end and complementary consensus sequencing (PECC-Seq), a high-accuracy ecNGS approach for genome-wide somatic mutation detection. We characterize a novel 2-aminoimidazolone lesion besides 7,8-dihydro-8-oxoguanine and the resulting end-repair artifacts originating from NGS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Consensus
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutagenesis

Share to Mutation

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 37870450
DOI: 10.1093/nar/gkad909
PMCID: PMC10681716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide direct quantification of in vivo mutagenesis using high-accuracy paired-end and complementary consensus sequencing.PMID 37870450Read ↗

Improved Mutation Detection in Duplex Sequencing Data with Sample-Specific Error ProfilesSemantic proximity Read ↗

Detection of genome-wide low-frequency mutations with Paired-End and Complementary Consensus Sequencing (PECC-Seq) revealed end-repair-derived artifacts as residual errors.Semantic proximity Read ↗

Application of next-generation sequencing in the detection of low-abundance mutations.Semantic proximity Read ↗

Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations.Semantic proximity Read ↗

Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment.Semantic proximity Read ↗

Direct Quantification of <i>in vivo</i> Mutagenesis and Carcinogenesis Using Duplex SequencingSemantic proximity Read ↗

Detection of genome-wide low-frequency mutations with Paired-End and Complementary Consensus Sequencing (PECC-Seq) revealed end-repair derived artifacts as residual errorsSemantic proximity Read ↗

A Universal Duplex Sequencing Approach for Accurate Detection of Somatic MutationsSemantic proximity Read ↗

Next-generation sequencing methodologies to detect low-frequency mutations: "Catch me if you can".Semantic proximity Read ↗

Click-chemistry-aided quantitation and sequencing of oxidized guanines and apurinic sites uncovers their transcription-linked strand bias in human cellsSemantic proximity Read ↗

Assessment of in vivo chemical mutagenesis by long-read sequencing.Semantic proximity Read ↗

Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.