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Article

Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations.

BMC genomics - 28 Jul 2022

LeBlanc Danielle P M, Meier Matthew, Lo Fang Yin, Schmidt Elizabeth, Valentine Charles, Williams Andrew, Salk Jesse J, Yauk Carole L, Marchetti Francesco

Abstract excerpt

Exposure to environmental mutagens increases the risk of cancer and genetic disorders. We used Duplex Sequencing (DS), a high-accuracy error-corrected sequencing technology, to analyze mutation induction across twenty 2.4 kb intergenic and genic targets in the bone marrow of MutaMouse males exposed to benzo(a)pyrene (BaP), a widespread environmental pollutant. DS revealed a linear dose-related induction of...

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Identifiers

PMID: 35902794
DOI: 10.1186/s12864-022-08752-w
PMCID: PMC9331077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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