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Article

Assessment of in vivo chemical mutagenesis by long-read sequencing.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2024

Miranda Jaime A, Revollo Javier R

Abstract excerpt

Evaluating the mutagenic properties of chemicals is crucial for understanding their potential cancer risks. Recent Illumina-based error-corrected sequencing techniques have enabled the direct detection of mutations induced de novo by mutagens. However, as the Illumina platform lacks intrinsic error-correction capabilities, complex library preparations and bioinformatic processes are necessary to identify these...

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PMID: 39141500
DOI: 10.1093/toxsci/kfae104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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