Article
Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing.
Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2020
Valentine Charles C, Young Robert R, Fielden Mark R, Kulkarni Rohan, Williams Lindsey N, Li Tan, Minocherhomji Sheroy, Salk Jesse J
Abstract excerpt
The ability to accurately measure mutations is critical for basic research and identifying potential drug and chemical carcinogens. Current methods for in vivo quantification of mutagenesis are limited because they rely on transgenic rodent systems that are low-throughput, expensive, prolonged, and do not fully represent other species such as humans. Next-generation sequencing (NGS) is a conceptually attractive...
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