Article
Orphan quality control shapes network dynamics and gene expression.
Cell - 3 Aug 2023
Mark Kevin G, Kolla SriDurgaDevi, Aguirre Jacob D, Garshott Danielle M, Schmitt Stefan, Haakonsen Diane L, Xu Christina, Kater Lukas, Kempf Georg, Martínez-González Brenda, Akopian David, See Stephanie K, Thomä Nicolas H, Rapé Michael
Abstract excerpt
All eukaryotes require intricate protein networks to translate developmental signals into accurate cell fate decisions. Mutations that disturb interactions between network components often result in disease, but how the composition and dynamics of complex networks are established remains poorly understood. Here, we identify the E3 ligase UBR5 as a signaling hub that helps degrade unpaired subunits of multiple...
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