Article

Modular HUWE1 architecture serves as hub for degradation of cell-fate decision factors

2020-08-19

Abstract excerpt

<h4>Summary</h4> HECT ubiquitin ligases play essential roles in metazoan development and physiology. The HECT ligase HUWE1 is central to the cellular stress response by mediating degradation of key death or survival factors including Mcl1, p53, DDIT4, and Myc. As a step toward understanding regulation of HUWE1 engagement with its diverse substrates, we present here the cryo-EM structure of HUWE1, offering a first...

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Literature Corpus work: 7d9147f8-c4ea-584d-9b33-5a1cf8d2e87b
DOI: 10.1101/2020.08.19.257352

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