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Article

Smurfs in Protein Homeostasis, Signaling, and Cancer

2 Aug 2018

Abstract excerpt

Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade essential for normal cellular functions and homeostasis maintenance. This pathway relies on a defined set of cellular enzymes, among them, substrate-specific E3 ubiquitin ligases (E3s). These ligases are the most critical players, as they define the spatiotemporal nature of ubiquitination and confer specificity to this...

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PMID: 30116722
DOI: 10.3389/fonc.2018.00295

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