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Quality control of protein complex assembly by the ubiquitin–proteasome system

14 Mar 2022

Abstract excerpt

The majority of human proteins operate as multimeric complexes with defined compositions and distinct architectures. How the assembly of these complexes is surveyed and how defective complexes are recognized is just beginning to emerge. In eukaryotes, over 600 E3 ubiquitin ligases form part of the ubiquitin-proteasome system (UPS) which detects structural characteristics in its target proteins and selectively...

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PMID: 35300891
DOI: 10.1016/j.tcb.2022.02.005

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